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To prevent desensitization of the melanocortin receptors and minimize skin darkening, medical guidelines recommend no more than one dose in 24 hours and a maximum of 8 doses per month

6a the highest (457.9 mg kg 1 DW) and the lowest (267.3 mg kg 1 DW) level of Fe was recorded at the level of 0.22 and 10 mg L 1 Zn, respectively while the highest level (436.3 mg kg 1 DW) of Fe was related to the control level (39 mg L 1 ) of K while the lowest level of Fe in spinach leaves was recorded at both 78 and 117 mg L 1 of K in nutrient solution (Fig